Severe thrombocytopenia associated with monkeypox infection
Keywords:
Autoimmune thrombocytopenia – Monkeypox – Emerging Infectious diseases
Abstract
Introduction: Secondary immune thrombocytopenia has been described in relation to autoimmune mechanisms during infection by different viruses.
Clinical Case: A 58-year-old male patient, diagnosed with HIV infection since 2012, under antiretroviral treatment with virological suppression consults the emergency service of a private clinic in the City of Buenos Aires due to painful cervical and axillary lymphadenopathies. Severe thrombocytopenia was confirmed by laboratory at admission, so hospitalization was decided. Perioral ulcerated maculopapular lesions are founded at examination. Monkeypox infection was confirmed by PCR in such lesions. Treatment with steroids was started, interpreting the condition as thrombocytopenia of autoimmune origin, with good clinical evolution.
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References
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3. Ponzetto, A., Figura, N., & Fiorini, G. (2018). Immune thrombocytopenic purpura and infections. Internal and Emergency Medicine, 13(7), 1137-1137. https://doi.org/10.1007/s11739-018-1908-9
4. Cines, D. B., Liebman, H., & Stasi, R. (2009). Pathobiology of secondary immune thrombocytopenia. Seminars in hematology, 46(1 Suppl 2), S2–S14. https://doi.org/10.1053/j.seminhematol.2008.12.005
5. Goldman M, Hermans C (2021) Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity. PLoS Med 18(5): e1003648. https://doi.org/10.1371/journal.pmed.1003648
6. World Health Organization. Multi-country monkeypox outbreak in non-endemic countries. Disponible en: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON385
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8. Pal, M., Mengstie, F., & Kandi, V. (2017). Epidemiology, Diagnosis, and Control of Monkeypox Disease: A comprehensive Review. American Journal of Infectious Diseases and Microbiology, 5(2), 94-99. DOI: 10.12691/ajidm-5-2-4
9. Patel, A., Bilinska, J., Tam, J. C., Fontoura, D. D. S., Mason, C. Y., Daunt, A., ... & Nori, A. (2022). Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series. bmj, 378. https://doi.org/10.1136/bmj-2022-072410
10. Biscayart, C., Ferrer, M. F., Otreras, Á., López, C., Lloveras, S., Cunto, E., ... & Angeletti, V. (2022). Viruela símica: zoonosis emergente con impacto global. Actualizaciones en Sida e Infectología. https://doi.org/10.52226/revista.v30i109.141
11. Huhn, G. D., Bauer, A. M., Yorita, K., Graham, M. B., Sejvar, J., Likos, A., ... & Kuehnert, M. J. (2005). Clinical characteristics of human monkeypox, and risk factors for severe disease. Clinical infectious diseases, 41(12), 1742-1751. https://doi.org/10.1086/498115
12. Cann, J. A., Jahrling, P. B., Hensley, L. E., & Wahl-Jensen, V. (2013). Comparative pathology of smallpox and monkeypox in man and macaques. Journal of comparative pathology, 148(1), 6-21. https://doi.org/10.1016/j.jcpa.2012.06.007
13. Downie, A. W., Fedson, D. S., St Vincent, L., Rao, A. R., & Kempe, C. H. (1969). Haemorrhagic smallpox. Epidemiology & Infection, 67(4), 619-629. https://doi.org/10.1017/S0022172400042078
Published
2023-11-21
How to Cite
Martin, Y., Braverman, A., Lapadula, P., & Pryluka, D. (2023). Severe thrombocytopenia associated with monkeypox infection. Actualizaciones En Sida E Infectología, 31(113). https://doi.org/10.52226/revista.v31i113.185
Section
Case Report
