Bacillary angiomatosis and Kaposi's sarcoma in skin lesion of HIV positive patient

Abstract

Bacillary angiomatosis (BA) is a rare infectious disease, caused by bacteria of the genus Bartonella spp, transmitted by vectors such as fleas, lice and mosquitoes. It causes different clinical syndromes in humans. In patients with human immunodeficiency virus (HIV) infection with an LT CD4 + <100 cell/μL count, it is associated with the development of angiomatous lesions with neovascularization involving the skin and, with less frequency, mucous membranes, liver, spleen and bones. Kaposi's sarcoma (KS) is a neoplasm characterized by multifocal vascular hyperplasia of endothelial origin related to human herpes virus 8. It can also compromiso the skin, mucous membranes and viscera, with the epidemic variant being a marker disease of advanced HIV infection. The main clinical differential diagnosis for KS skin and mucosal lesions is the BA.

Herein we present a patient with HIV/AIDS disease that developed BA and KS concomitantly in the same skin lesion.

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Author Biographies

Natalia Soledad Vittar

Unidad 11, Hospital de Infecciosas F J Muñiz, CABA, Argentina

Javier José Ricart

Unidad 11, Hospital de Infecciosas F J Muñiz, CABA, Argentina

Laura Gabriela Moreno Macías

Unidad 11, Hospital de Infecciosas F J Muñiz, CABA, Argentina

Jorge Velázquez

Unidad 11, Hospital de Infecciosas F J Muñiz, CABA, Argentina

Esteban Maronna

Anatomía patológica, Hospital de Infecciosas F J Muñiz, CABA, Argentina

Marcelo Corti

División B VIH/SIDA, Hospital de Infecciosas F J Muñiz, CABA, Argentina

References

1. Stoler MH, Bonfiglio TA, Steigbigel RT et al. An atypical subcutaneous infection associated with acquired immune deficiency syndrome. Am J Clin Pathol. 1983; 80: 714–718.
2. Velho P, Cintra M, Uthida-Tanaka A et al. What do we (not) know about the human bartonelloses? Braz J Infect Dis. 2003; 78: 601-609.
3. Gasquet S, Maurin M, Brouqui P et al. Bacillary angiomatosis in inmunocompromised patients. AIDS. 1998; 12: 1973-1803
4. Billeter SA, Levy MG, Chomel BB et al. Vector transmission of Bartonella species with emphasis on the potential for tick transmission. Med Vet Entomol. 2008; 22: 1–15.
5. Forrestel AK, Naujokas A, Martin JN et al. Bacillary angiomatosis masquerading as Kaposi's sarcoma in East Africa. J Int Assoc Provid AIDS Care. 2015; 14: 21–25.
6. Corti M, Villafane MF, Metta H et al. Detection of Kaposi´s sarcomaassociated human herpes virus type 8 DNA in biopsy smears of human immunodeficiency virus-infected patients. Glob Dermatol. 2016; 3: 238-240.
7. Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi’s sarcoma in patients with and those without HIV infection. N Engl J Med. 1995; 332: 1181-1185.
8. Radu O, Pantanowitz L. Kaposi Sarcoma. Arch Pathol Lab Med. 2013; 137: 289–294.
9. Pantanowitz L, Dezube BJ. Kaposi sarcoma in unusual locations. BMC Cancer. 2008; 8:190.
10. Corti M, Villafañe M, Castello T et al. Angiomatosis bacilar con peliosis hepática en un paciente con SIDA. Revista Medicina. 2006; 66: 153.
11. Cortes EE, Saraceni V, Medeiros D et al. Bacillary angiomatosis and Kaposi’s sarcoma in AIDS. AIDS Patient Care and STDS. 2000; 14: 179–182.
12. Grayson W. Recognition of dual or multiple pathology in skin biopsies from patients with HIV/AIDS. Patholog Res Int. 2011.
13. LeBoit PE, Berger TG, Egbert BM et al. Bacillary angiomatosis. The histopathology and differential diagnosis of a pseudoneoplastic infection in patients with human immunodeficiency virus disease. Am J Surg Pathol. 1989; 13: 909–920.
14. Koehler JE, Tappero JW. Bacillary angiomatosis and bacillary peliosis in patients infected with human immunodeficiency virus. Clin Infect Dis. 1993. 17: 612–624.
15. Correa J, Villafane MF, De Carolis L, Corti M, Sforza R et al. Diagnosis of Bacillary Angiomatosis and Kaposi´s Sarcoma in the same skin lesion in a patient with recent HIV/AIDS diagnosis. Clin Dermatol Res Ther 2017; 1: 113-7.
Published
2023-07-24
How to Cite
Cárdenas, G. L., Vittar, N. S., Ricart, J. J., Moreno Macías, L. G., Velázquez , J., Maronna, E., & Corti, M. (2023). Bacillary angiomatosis and Kaposi’s sarcoma in skin lesion of HIV positive patient. Actualizaciones En Sida E Infectología, 31(112). https://doi.org/10.52226/revista.v31i112.179
Section
Case Report