Daptomycin-resistant enterococcus faecium bacteremia – case report in hospital from Bogotá, Colombia

Keywords: Enterococcus, Enterococcus Faecium, Antibiotic Resistance, Daptomycin Resistance

Abstract

In recent years, the emergence of daptomycin-resistant enterococcus strains is a growing clinical and epidemiological topic of concern. We report the case of a 50-year-old patient with an antecedent of rheumatoid arthritis and chronic immunosuppression hospitalized in the context of COVID-19 pneumonia with bacterial co-infection and septic shock in which a three different moments an isolate of a vancomycin-resistant enterococcus faecium (VRE) VAN A and B that presented therapeutic failure with daptomycin was documented after clinical deterioration and persistence of positive blood cultures. Linezolid was initiated, with clinical recovery and negativization of blood cultures following the change in antibiotic treatment. This case is reported in order to expose the ever growing concern of daptomycin-resistant enterococcus strains in order to prevent therapeutic failure, make early identification and get to know the local epidemiological status.

Downloads

Download data is not yet available.

Author Biographies

Mateo Rodríguez-Giraldo, Fundación Cardioinfantil

Interno institucional de la Fundación Cardioinfantil.

Lina Patricia Vargas-Nieto, Fundación Cardioinfantil

Médico internista de la Fundación Cardioinfantil.

Sergio Alzate-Ricaurte, Fundación Cardioinfantil

Interno institucional de la Fundación Cardioinfantil.

Felipe Hernández-Huertas, Fundación Cardioinfantil

Interno institucional de la Fundación Cardioinfantil.

Jose Miguel Gnecco Giraldo, Fundación Cardioinfantil

Interno institucional de la Fundación Cardioinfantil.

Jose Gabriel Montenegro-Vargas

Interno institucional de la Fundación Cardioinfantil.

References

1) Caicedo-Ochoa EY, Urrutia-Gómez JA, Fernández-Niño DS, Guío-Guerra SA, Méndez-Fandiño YR. Tratamiento de la bacteriemia por enterococo resistente a vancomicina con daptomicina versus linezolid: revisión sistemática y metanálisis TT - Treatment of bacteremia by vancomycin-resistant Enterococcus with daptomycin versus linezolid: a systematic re. Iatreia [Internet]. 2017;30(1):5–20. Available from: http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/24199

2) Munoz-Price LS, Lolans K, Quinn JP. Emergence of resistance to daptomycin during treatment of vancomycin-resistant Enterococcus faecalis infection [1]. Clin Infect Dis [Internet]. 2005 Aug 15 [cited 2021 Nov 26];41(4):565–6. Available from: https://academic.oup.com/cid/article/41/4/565/340551

3) Sabol K, Patterson JE, Lewis JS, Owens A, Cadena J, Jorgensen JH. Emergence of Daptomycin Resistance in Enterococcus faecium during Daptomycin Therapy. Antimicrob Agents Chemother [Internet]. 2005 Apr;49(4):1664–5. Available from: https://journals.asm.org/doi/abs/10.1128/AAC.49.4.1664-1665.2005

4) Kelesidis T, Humphries R, Uslan DZ, Pegues DA. Daptomycin Nonsusceptible Enterococci: An Emerging Challenge for Clinicians. Clin Infect Dis [Internet]. 2011 Jan 15; 52(2):228–34. Available from: https://academic.oup.com/cid/article/52/2/228/375903

5) Campeau SA, Schuetz AN, Kohner P, Arias CA, Hemarajata P, Bard JD, et al. Variability of daptomycin MIC values for enterococcus faecium when measured by reference broth microdilution and gradient diffusion tests. Antimicrob Agents Chemother [Internet]. 2018 Sep 1;62(9). Available from: https://journals.asm.org/doi/abs/10.1128/AAC.00745-18

6) Bazet C, Blanco J, Seija V, Palacio R. Enterococos resistentes a vancomicina: un problema emergente en Uruguay. Rev Médica del Uruguay [Internet]. 2005;21(2):151–8. Available from: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-03902005000200007

7) Manassero NC, Navarro M, Rocchi M, Bella H, Gasparotto AM, Oca AV, et al. Y Sensibilidad a Los Antimicrobianos. 2016;48(4):298–302. Available from: https://www.elsevier.es/es-revista-revista-argentina-microbiologia-372-articulo-analisis-117-episodios-bacteriemia-por-S0325754116300426
ASEI 110 Mateo
Published
2022-12-07
How to Cite
Rodríguez-Giraldo, M., Vargas-Nieto, L. P., Alzate-Ricaurte, S., Hernández-Huertas, F., Gnecco-Giraldo, J. M., & Montenegro-Vargas, J. G. (2022). Daptomycin-resistant enterococcus faecium bacteremia – case report in hospital from Bogotá, Colombia. Actualizaciones En Sida E Infectología, 30(110). https://doi.org/10.52226/revista.v30i110.119