Fagoterapia: una alternativa emergente en la era de la multirresistencia antibiótica
Palabras clave:
fagoterapia, bacteriófagos, fagos, infecciones difíciles de tratar, resistencia antimicrobiana
Resumen
La creciente resistencia antimicrobiana asociada a la crisis en la producción de nuevos antibióticos y las consecuencias humanas y económicas de este fenómeno, constituyen un complejo escenario que requiere el urgente desarrollo de estrategias antimicrobianas alternativas. Los bacteriófagos son virus que infectan y lisan bacterias. Se conocen desde hace más de un siglo pero en las últimas dos décadas, la administración de bacteriofagos ha ganado popularidad en todo el mundo. Existe un extenso cuerpo de evidencia preclínica y clínica que posiciona a la fagoterapia como una de las principales herramientas para el tratamiento de infecciones difíciles de tratar. Si bien esto es conceptualmente promisorio, su implementación está limitada por la escasez de datos clínicos de seguridad y eficacia, obtenidos acorde a los estándares científicos actuales. Esta revisión describe los datos más relevantes acerca de la biología de los fagos, los aspectos farmacocinéticos y farmacodinámicos conocidos hasta la actualidad, los temas regulatorios y los resultados clínicos más relevantes.
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Citas
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Publicado
2023-07-24
Cómo citar
Guzzi, L. (2023). Fagoterapia: una alternativa emergente en la era de la multirresistencia antibiótica. Actualizaciones En Sida E Infectología, 31(112). https://doi.org/10.52226/revista.v31i112.123
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